1:1:1-Trichloro-2:2-di-(p-chlorophenyl)ethane (DDT) and rat adipose tissue

1:1:1-Trichloro-2:2-di-(p-chlorophenyl)ethane (DDT) and rat adipose tissue.

Metabolic Fate of P,p'-ddt (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane)in Rats.

* Inquiries regarding this paper should be addressed to M. S. Dunn, University of California, Los Angeles. The experimental data are from a dissertation submitted by Joseph D. Pinto to the Graduate School of the University of California, Los Angeles, in partial fulfillment of the requirements for the degree of Doctor of Philosophy. The chemical names and structures for DDT and its derivatives, ...

Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450.

The in vitro metabolism of p,p'-DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane], an important environmental pollutant, was examined in rat liver, focusing on reductive dechlorination. When p,p'-DDT was incubated with liver microsomes of rats in the presence of NADPH or NADH, a dechlorinated metabolite, p,p'-DDD [1,1-dichloro-2,2-bis(4-chlorophenyl)ethane], was formed under anaerobic conditi...

Food consumption and adipose tissue DDT levels in Mexican women.

This article analyzes food consumption in relation to levels of DDE (the principal metabolite of DDT) in the adipose tissue of 207 Mexican women residing in States with high and low exposure to DDT. Data on the women's dietary habits and childbearing history were obtained from a personal interview. Adipose tissue DDE levels were measured by gas-liquid chromatography and compared by analysis of ...

Protein-mediated transfer of DDT to adipose tissue.

The in vitro transfer of DDT through various media to rat adipose tissue was examined. About 15% of DDT was transferred through Krebs-Ringer solution to the tissue slices after 2-hr incubation at 37 degrees C. The addition of albumin accelerated the transfer of DDT proportionally to the concentrations up to 1.0%. Hemoglobin and gamma-globulin showed a lesser accelerating activity, but protamine...